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  2. Universiteit Utrecht (UU)
  3. Postdoc position in nanobody-based immunotherapy of cancer (1.0 FTE)

Postdoc position in nanobody-based immunotherapy of cancer (1.0 FTE)

Development of nanobodies binding to peptide-MHC complexes for the next level of immunotherapy against cancer.

18 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Domplein, Utrecht, Utrecht
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 40 uur
Salarisindicatie:
€ 2709 - € 4274 per maand
Opleidingsniveau:
WO

Functieomschrijving

Despite recent improvements in immunotherapy, cancer still is a major threat to humans in western societies. To further improve the immunotherapy of cancer we have started a collaboration with the pharmaceutical company Apo-T. This therapy is based on the application of nanobodies: antibody fragments obtained from Llama’s. The project aims to generate nanobodies binding to tumor specific markers, which are presented on the surface of cancer cells as complexes of peptides bound to MHC-I proteins.

Within the project, nanobodies will be developed binding to peptide/MHC-complexes. Peptides are derived from MAGE-A, which is an intracellular biomarker for the early events of oncogenic transformation, tumor invasion and metastasis. As the Postdoc Researcher you will, together with a technician, fully characterize the obtained nanobodies using structural and cell biology methods. In addition, you will investigate the application of the novel nanobodies to specifically kill cancer cells. Different approaches will be evaluated: nanobody-drug conjugates, bispecific T-cell engagers (BITE) and/or CAR-T cells.

Functie-eisen

To excel in this role you enjoy being part of a driven multidisciplinary team. Furthermore, you are a motivated Postdoctoral Researcher with interest in the further applications of nanobodies in immunotherapy of cancer and you have:

  • a PhD in molecular and cell biology;
  • experience in structural biology, and immunology;
  • experience with protein chemistry and phage display (considered an advantage);
  • excellent verbal and written communication skills in English.

Conditions

  • a position for at least 1 year;
  • a full-time gross salary ranging from €2,709 to €4,274 in scale 10;
  • benefits including 8% holiday bonus and 8.3% end-of-year bonus;
  • a pension scheme, partially paid parental leave, and flexible employment conditions (based on the Collective Labour Agreement Dutch Universities).


In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model. This is how we like to encourage you to continue to grow.

More information about working at the Faculty of Science can be found here.

Additional information

If you have any questions, please contact Dr Paul van Bergen en Henegouwen (Associate Professor Cell Biology) via P.vanBergen@uu.nl. Please do not send your application to this email address, but use the online application portal.

Questions about the application procedure? Send an email to science.recruitment@uu.nl.

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