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PhD candidate (AIO) FHML/School for Cardiovascular Diseases/CARIM- Dept. of Physiology

The RACE-V network brings together researchers from Groningen, Maastricht and Leiden. Together, we are investigating how AF affects coagulation factors both in the blood and in atrial tissue and how these factors in turn alter the atrial tissue and lead to progression of AF.

2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Robert Schumandomein, Maastricht, Limburg
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 40 uur
Salarisindicatie:
€ 2222 - € 2840 per maand
Opleidingsniveau:
WO

Functieomschrijving

The RACE-V network brings together researchers from Groningen, Maastricht and Leiden. Together, we are investigating how AF affects coagulation factors both in the blood and in atrial tissue and how these factors in turn alter the atrial tissue and lead to progression of AF.

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. The risk of AF increases with age, and because the general population is ageing, the number of AF patients is expected to increase substantially in the coming decades. One of the most harmful consequences of AF is the formation of emboli that can lead to debilitating and life-threatening strokes. It is generally accepted that AF leads to changes in blood coagulation. However, we have recently demonstrated that alterations in coagulation factors can also contribute to the progression of AF. This bidirectional interaction between AF and coagulation is the main theme of the national network RACE-V ('Reappraisal of Atrial Fibrillation: Interaction between hyperCoagulability, Electrical remodeling, and Vascular Destabilization in the Progression of AF', www.race-v.org), funded by the Dutch Heart Foundation. In this team, investigators from several disciplines, both basic scientists and clinicians, and various universities (Maastricht, Groningen and Leiden) collaborate. Our AF research group is part of CARIM, the CArdiovascular Research Institute Maastricht (www.carimmaastricht.nl). In this PhD project, the interaction between AF and coagulation will be studied in animal models of paroxysmal AF (i.e. intermittent episodes of AF) and heart failure. The disease mechanisms identified in these models can then be studied in atrial biopsies and blood samples collected in AF patients.

Functie-eisen

MSc in Medicine, (Medical) Biology, or a related discipline. Experience in electrophysiology or animal models are advantageous.

Conditions

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website https://www.maastrichtuniversity.nl/support/um-employees

Additional information

Prof dr U. Schotten, dept Physiology

Dr S. Verheule, dept Physiology