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  3. PhD Position in Computational Toxicology (1.0 FTE)

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PhD Position in Computational Toxicology (1.0 FTE)

Would you like to make a contribution to the development of computational approaches to the toxicological risk assessment of cardiotoxic chemicals?

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Domplein, Utrecht, Utrecht
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 40 uur
Salarisindicatie:
€ 2395 - € 3061 per maand
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

The Veterinary and Comparative Pharmacology Group of the Institute of Risk Assessment Sciences at Utrecht University is looking for a PhD candidate to contribute to the development of computational approaches to the toxicological risk assessment of cardiotoxic chemicals.
As our PhD candidate you will develop physiologically-based kinetic (PBK) models and other computational approaches to analyze, synthesize and extrapolate toxicokinetic and toxicodynamic data generated by new approach methodologies (NAMs) for chemical risk assessment. You will be part of an international multi-disciplinary team that uses innovative in vitro, -omics and computational approaches to study the effects of chemicals on cardiac tissue. One of your tasks will be to perform a systematic review and integrate toxicological evidence from the literature to identify chemical compounds, associated with adverse cardiovascular health outcomes. Your focus will be to develop mechanistic, biologically based models that predict chemical concentrations at target sites in the body (reverse dosimetry), and in such a manner that in silico and in vivo data can be extrapolated to in vivo exposure scenarios and case studies.

Functie-eisen

You are/have:

  • an MSc degree in life sciences, biology, toxicology, pharmacology, (veterinary) medicine or a relevant related field;
  • excellent English proficiency (both written and spoken);
  • a strong computational and analytical background with experience in using common modeling and statistical software (e.g., Matlab, R, Berkley Madonna, Phoenix, Monolix or NONMEM);
  • persistent, curious, meticulous, willing to learn and you understand the bigger picture.

Conditions

You will be offered a temporary position (1.0 FTE) for a period of four years. The gross salary ranges between €2,395 in the first year and €3,061 in the fourth year of employment (scale P according to the Collective Labour Agreement Dutch Universities) per month for a full-time employment. Salaries are supplemented with a holiday bonus of 8% and a year-end bonus of 8.3% per year. In addition, Utrecht University offers excellent secondary conditions, including an attractive retirement scheme, (partly paid) parental leave and flexible employment conditions (multiple choice model). More information about working at Utrecht University can be found here.

Additional information

For more information about this position, please contact:
Ronette Gehring (Professor of Veterinary Pharmacotherapy and Pharmacy), via r.gehring@uu.nl.