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Post-doc Human intestine-on-a-chip

Are you interested in studying nutrient-intestine interaction in state-of-the-art in vitro models? Do you enjoy setting up and benchmarking 3D-cellular …

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Arbeidsvoorwaarden

Standplaats:
Droevendaalsesteeg, Wageningen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

Are you interested in studying nutrient-intestine interaction in state-of-the-art in vitro models? Do you enjoy setting up and benchmarking 3D-cellular models? Do you want to be part of a team of scientists from different WUR chair groups and industrial partners? Then we have an interesting position for you at Wageningen University and Research.

We are looking for an enthusiastic and motivated post-doctorate cell biologist with affinity for immunology and/or microbiology and experienced in developing cell models that closely mimic human physiology. You will take the lead in setting up an intestine-on-a-chip cellular model system in which you combine immune cells, intestinal epithelial cells, and microbiota. Together with the project team you will benchmark the system by analyzing immune, barrier and metabolic functions of the intestine in the intestine-on-chip model in response to nutritional and environmental stimuli using state-of-the-art detection methods. Next to building and benchmarking the model, you have the ambition to understand the effects of food ingredients and nutrients on intestinal physiology. As part of the chair group, you will also be involved in training MSc and BSc students, and you will work with technicians from other WUR institutes.

About the project
The INIMINI-health project focuses on innovative 'organ-on-chip' technology by combining multiple cell culture systems, cellular metabolism, and molecular biology readout parameters. The project delivers organotypic in vitro cell model systems with enhanced predictive value for in vivo impact of food, nutraceuticals, and pharmaceuticals. It will reduce the need for undesirable animal testing and (costly) human trials and can serve as a medium-throughput screening model. Moreover, a next step in development is a fully personalized INIMINI-health model. With minimally invasive procedures, it is possible to acquire immune cells, microbiota, and epithelial cells from a single donor to be grafted onto the INIMINI-health model which will establish a next step in personalized care and medicine.

The project is a collaboration between Wageningen University chair groups (Human and Animal Physiology; Toxicology; Cell Biology and Immunology), Wageningen Food and Biobased Research and industrial partners. The project team consists of staff scientists, research technicians and experts from industry.

About the chair group
You will be appointed at Human and Animal Physiology with ~30 employees, including technicians, PhD students, post-docs, junior and senior scientists working on fundamental and translatable questions related to physiology. HAP performs experimental research in humans, animals, tissues, and cells, using state-of-the-art physiological, molecular, biochemical, and histological tools. Results of our research are i) new mechanistic insights in metabolism related to health and organ functioning and, ii) methodology and data to substantiate the efficacy of interventions, compounds, and foods to improve metabolic health. You will also work at Wageningen Food and Biobased Research (WBFR) at the subdivision Food, Health, and Consumer Research. WBFR develops insights and technologies that support companies, governments, and other research institutes in creating innovative solutions for a healthier, more sustainable and prosperous world.

Functie-eisen

  • You have successfully completed a PhD degree in cell biology (or a similar field) and have proven skills in setting up and benchmarking cell biological in vitro systems.
  • You have a strong background in experimental science and can prove that you have the ability to perform independent lab work.
  • Experience in working with human (stem cell-based) cell cultures, molecular biology techniques (i.e. cytotoxicity assays, qPCR, metabolic assays such as Seahorse XF analysis), confocal microscopy, and -omics techniques will be considered as a pre.
  • You are a team player with the wish to contribute to the group overall aim have affinity for the collaborative nature of this project.
  • You have excellent communication skills, both oral and written.
  • You are willing to contribute to mentoring and teaching MSc and BSc students that work with you on the project
  • You work in an accurate and efficient way, and you are highly motivated to do science.

Conditions

Wageningen University & Research offers excellent terms of employment. A few highlights from our Collective Labour Agreement include:
  • sabbatical leave, study leave, and paid parental leave;
  • working hours that can be discussed and arranged so that they allow for the best possible work-life balance;
  • the option to accrue additional holiday hours by working more, up to 40 hours per week;
  • there is a strong focus on vitality and you can make use of the sports facilities available on campus for a small fee;
  • a fixed December bonus of 8.3%;
  • excellent pension scheme.
In addition, we offer depending on your experience, a competitive salary from a minimum of € 2.790,- to a maximum of € 4.402 for Post-Doc (scale 10), for a full working week of 38 hours in accordance with the Collective Labor Agreement Dutch Universities. The job is for a period of 3 years (1 year after a positive evaluation extension for another 2 years) at an international leading organization.

Wageningen University & Research encourages internal advancement opportunities and mobility with an internal recruitment policy. There are plenty of options for personal initiative in a learning environment, and we provide excellent training opportunities. We are offering a unique position in an international environment with a pleasant and open working atmosphere.

You are going to work at the greenest and most innovative campus in Holland, and at a university that has been chosen as the "Best University" in the Netherlands for the 16th consecutive time.

Coming from abroad
Wageningen University & Research is the university and research centre for life sciences. The themes we deal with are relevant to everyone around the world and Wageningen, therefore, has a large international community and a lot to offer to international employees. Applicants from abroad moving to the Netherlands may qualify for a special tax relief, known as the 30% ruling. Our team of advisors on Dutch immigration procedures will help you with the visa application procedures for yourself and, if applicable, for your family.

Feeling welcome also has everything to do with being well informed. Wageningen University & Research's International Community page contains practical information about what we can do to support international employees and students coming to Wageningen. Furthermore, we can assist you with any additional advice and information about helping your partner to find a job, housing, schooling, and other issues.

Additional information

For more information about this position, please contact Vincent de Boer, vincent.deboer@wur.nl, assistant professor at Human and Animal Physiology, or Paul Vos, paul.vos@wur.nl expertise leader Food-based Health Screening.

For more information about the procedure, please contact Eliene Veneberg, HR advisor, eliene.veneberg-boogaard@wur.nl.

Do you want to apply?
You can apply directly using the apply button on the vacancy page on our website which will allow us to process your personal information with your approval.

This vacancy will be listed up to and including August 22nd 2021.

Equal opportunities
Wageningen University & Research (WUR) employs a large number of people with very different backgrounds and qualities, who inspire and motivate each other. We want every talent to feel at home in our organisation and be offered the same career opportunities. We therefore especially welcome applications from people who are underrepresented at WUR. For more information please go to our inclusivity page. A good example of how WUR deals with inclusiveness can be read on the page working at WUR with a functional impairment.