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PhD Smart leads for (preventing) OA: deciphering the network that regulates chondrocyte cell fate.

Articular cartilage is a highly resilient tissue that covers the surfaces at the ends of long bones. Because of its lubricating properties, it ensures the pain-free and supple movements of our joints. Cartilage has a ...

7 maanden geleden


Drienerlolaan, Enschede, Overijssel
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
€ 2222 - € 2840 per maand


Articular cartilage is a highly resilient tissue that covers the surfaces at the ends of long bones. Because of its lubricating properties, it ensures the pain-free and supple movements of our joints. Cartilage has a very low self-repairing ability and damage to cartilage induces a gradual process towards osteoarthritis. In this project, we will use a computational model of the chondrocyte to predict the signals determining the switch from articular to osteoarthritic cartilage. The model-predictions will be validated using a combination of traditional molecular biology techniques and advanced biophysical methods, including FRAP, to map gene regulatory mechanisms in a spatial and temporal manner.


  • You hold a master’s degree in Biomedical Engineering, Molecular (Cell) Biology, Biophysics or an equivalent master’s education;
  • You have excellent analytical skills;
  • You have a strong interest in computational modeling (of signal transduction networks);
  • You have experience in experimental cell culture, molecular biology techniques, and fluorescence microscopy techniques. Experience in analysis of big data (transcriptomics, proteomics) and chondrogenesis/cartilage will be considered a benefit;
  • You are a team player with good communication skills;
  • You are fluent in English, both spoken and written.

Information and application:
For inquiries about this position and our offer you can contact Dr. Janine Post (j.n.post@utwente.nl).

Candidates should upload their application by using the application button below, including a motivation letter, a curriculum vitae and a list of publications (when applicable).

Key words: cartilage repair, molecular biology, osteoarthritis, regenerative medicine, confocal microscopy, biophysics, proteomics, computational modeling.


The University of Twente offers a stimulating work environment in an area of applied, forefront research. We offer a PhD position in a project sponsored by the Dutch Arthritis Foundation (Reumafonds). You will have a full-time employment contract for the duration of 4 years and can participate in all employee benefits the UT offers. The gross monthly salary starts with € 2.222,- in the first year and increases to € 2.840,- in the fourth year of your employment. Additionally, the University of Twente provides excellent facilities for professional and personal development, a holiday allowance (amount to 8%) and an end of year bonus of 8.3%. A high-quality training program is part of the agreement. The research has to result in a PhD thesis at the end of the employment period.


The University of Twente. We stand for life sciences and technology. High tech and human touch. Education and research that matter. New technology which leads change, innovation and progress in society. The University of Twente is the only campus university of the Netherlands; divided over five faculties we provide more than fifty educational programmes. We have a strong focus on personal development and talented researchers are given scope for carrying out groundbreaking research.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status or disability status. Because of our diversity values we do particularly support women to apply.

Within the TNW Faculty (Faculty of Science & Technology) of the University of Twente some 700 staff members and 2000 students are involved in training and research on the interface of chemical technology, applied physics and biomedical technology. Fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. Research, which enjoys a high profile both at home and internationally, has been accommodated in the multidisciplinary research institutes MESA+ and MIRA. The faculty works together intensively with industrial partners and researchers in the Netherlands and abroad and conducts extensive research for external commissioning parties and funders.